How does absorption influence poison of the molecules?
Understanding of the method of absorption is important in determining why some molecules are so poisonous. Poison has the greatest chance of being harmful if it can access a large amount of cells and therefore the xenobiotic must be absorbed by the body. In addition to this if a xenobiotic can effectively be absorbed, then this will increase the dosage of the substance in the blood and the toxicity, increasing the potential harm and therefore by definition increase how poisonous the molecule is. It should be noted injecting the poison into the bloodstream instead of the molecule being absorbed. This increases toxicity and reduces the LD50 and NOEL by producing a shorter but larger spike in the concentration of the poison in one area of the organism, and reducing the time taken to reach the target organ and cause adverse effects.