What is the definition of prostate cancer?

Asked on 21.11.2018 in All Questions.
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Prostate cancer represents a clinically heterogeneous disease with current treatments based on anatomical and pathological parameters. The progress in sequencing strategies has revealed genomic alterations in prostate cancer that represent clinically targetable defects and potential biomarkers. Genomic alterations in the PI3K-AKT pathway, particularly PTEN are found to be common in prostate cancer, with compounds targeting various kinases in this pathway showing promise in clinical trials. Germline and somatic defects in DNA repair genes are another avenues of potentially clinical defects, being shown to sensitize patients to PARP inhibition and drugs such as olaparib which has shown potential in phase ll clinical trials. Finally, mutations in genes involved in...
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