What happens in the PI3K–AKT pathway?

Asked on 22.11.2018 in All Questions.
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The use of sequencing has shown that in 20-40% of primary tumors and 49% CRPCs genetic alterations in the PI3K-AKT pathway are present. The genomic alterations impact tumorigenesis through the activation of target genes, resulting in cell growth, the progression of cell cycle and proliferation. It has been shown that hyperactivity of the PI3K-AKT pathway seems to be most commonly as a result of PTEN activation. However, other alterations such as those in PIK3CA, PIK3CB, PIK3R1, PIK3R3, and AKT1 also play a role in PI3K-AKT hyperactivity. Of note seems to...
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