What are the main subgroups of the metastatic prostate cancer?

Asked on 21.11.2018 in All Questions.
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Metastatic prostate cancer can be subdivided into two subgroups: hormone-sensitive prostate cancer (HSPC). Which response to androgen ablation and castration-resistant prostate cancer (CRPC), which develops resistance to gonadal suppression. Bilateral orchiectomy currently represents the gold standard for metastatic HSPC although gonadal suppression is currently accomplished through the use of gonadotropin-releasing hormone agonists or antagonists with or without androgen receptor blockade. It is this approach that remains the go-to therapy for those with metastatic HSPC. Recent data from stage all trials have also suggested a substantial survival benefit in the treatment of patients with combination therapy of docetaxel and androgen deprivation in metastatic HSPC. However, despite these treatment options, most individuals suffering from metastatic HSPC will eventually progress the CRPC, the lethal stage of the disease. For...
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