What is the molecular structure of the poison?
The molecular structure of the poison is a crucial factor in determining the toxicity of a molecule and therefore how poisonous the molecule is. A highly poisonous molecule or a molecule with high toxicity has got to effectively enter the organism and effect its cells. Therefore a molecule that is lipid soluble can easily pass through the partially permeable phospholipid bilayer and be able to bind to the molecules in the blood during distribution which means that soluble lipid molecules have a greater potential to cause harm. Likewise, hydrophilic molecules can easily dissolve in the plasma of the blood due to its 75% water composition, allowing it to be effectively transported around the body. If the molecule has functional groups with a high difference in electronegativity or has charged elements, then it is likely that the molecule will have greater interactions with biological molecules, making them potentially more harmful to the body and therefore more poisonous.