What is the percentage of the DNA repair defects found in patients with progressing to advanced prostate cancer?

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Germline alterations in DNA repair genes have been found to occur in roughly 12% of men progressing to advanced prostate cancer, while somatic alterations are found in upwards of a quarter of all CRCPCs. Mutations in genes involved in homologous recombination (HR) such as BRCA1/2, PALB2, and ATM are frequently deleteriously mutated in CRPC. These mutations in DNA repair have critical clinical consequences such as those seen in patients harboring deleterious germline BRCA2 mutations being at increased prostate cancer risk. Cancers possessing defects in HR repair represents an attractive target in the treatment of metastatic castration-resistant prostate cancer. One such drug to come out of this is olaparib, which,...
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