When is synaptic glutamate released?

Asked on 11.10.2018 in All Questions.
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In neurovascular signalling that regulated by glutamate neurotransmitter, when neural activity increases synaptic glutamate is released and binds to NMDA receptors on adjacent neurons and metabotropic glutamate receptors on astrocytes. As a result, intracellular calcium ([Ca2+] i) increases in each of neurons and astrocytes, activating the secretion of vasoactive compounds. In astrocytes, the increased [Ca2+] I leads to the activation of phospholipase A2 (PLA2) which in turn produce arachidonic acid (AA).  AA is released at the...
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