What is the noradrenaline?

Asked on 30.12.2018 in All Questions.
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Noradrenaline is a catecholamine that functions as a neurotransmitter inside the human brain. Once released by the pre-synaptic neuron, it exerts its effects by binding to and activating receptors on the surface of the cell. The two broad families of noradrenaline receptors are alpha and beta-adrenergic. The former is divided into the subtype’s a1 and a2, the beta receptors into b1, b2, and b3. Alpha-2 receptors, often located pre-synaptically, typically have inhibitory effects on noradrenaline release. The other subtypes all have excitatory effectors. When noradrenaline binds to excitatory, post-synaptic receptors at a threshold level, the receptor activation creates a synaptic potential, a response in the post-synaptic neuron. If noradrenaline instead binds to pre-synaptic alpha-2 receptors at a threshold level, further noradrenaline release from the pre-synaptic neuron will be inhibited. This mechanism is referred to as feedback inhibition. The effects of noradrenaline can be terminated upon reuptake into the pre-synaptic...
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