When was the depth of toxicology?

Following this the depth of toxicology has continued to increase with Magendie, (1783-1885), detailing the absorption and distribution of various substances inside the body while Rachel Carson wrote the controversial book, The Silent Spring, in 1962. The book was incredibly influential in initiating and raising awareness of environmental toxicology, emphasising the effects of and reasons for banning widespread usages of pesticides and other potentially harmful chemicals. In the twentieth and twenty-first centuries there have been significant increases in the understanding of the adverse effects of xenobiotics on organs and cells at a molecular level. It is now recognized that almost all effects of poisons are as a result of specific changes in specific cellular molecules and biochemicals.